Research project

Development of retinal spectrometry for the identification of new early biomarkers of Parkinson's disease

Description

The regulation of retinal blood flow and oxygenation are recognized as root causes of the majority of ocular diseases, such as glaucoma. There is thus a huge interest in measuring these parameters in vivo, ideally using non-invasive methods. Retnia's technology, based on optical spectroscopy, enables such non-invasive measurements in laboratory and clinical settings. Recently, there has been growing evidence that many neurodegenerative diseases also have an effect on the retina, which is part of the central nervous system. Of the many neurodegenerative diseases that could possibly be sensed in the eye, Parkinson's disease (PD) stands out, due to the retina's similarities to the substantia nigra, a midbrain region that is known to degenerate in PD. PD affects more than 100 000 Canadians and is considered as the second most common neurodegenerative disease.

Some disease-modifying treatments exist but drugs that have been tested have provided disappointing results. This can be largely explained by the fact that the cardinal symptoms of PD typically manifest only when more than half of dopaminergic neurons in the substantia nigra are lost. Therefore, early biomarkers of PD are urgently needed to succeed in disease-modifying therapies. In the proposed research project, we will use
Retnia's multimodal imaging device to perform spectroscopy on the retina of healthy and parkinsonian monkeys in order to identify and locate optical biomarkers in the form of hemoglobin and melanin retinal content and abnormalities, for early detection of PD.

Research Field

- Physics
- Physical Engineering
- Neurophotonics
- Biophotonics

Research Supervisor

Daniel Côté

Research Environment

CERVO research Centre

Web Site


Financial Aid Available by Program of Study

Doctorate in Biophotonics

Program description

Financial Aid Available*

Financial Aid Related to Research Project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Progression scholarship
7 x $500
Doctoral exam or seminar presentation
$750
Doctoral exam, seminar or conference
$1,000
Publication
$750
Communication
$1,000
First submission of dissertation
$1,000*
Total $8,500

*A $500 bonus will be added to the graduation scholarship if the initial submission is made before the semester preceding the final qualifying semester.

Université Laval: Student Financial Aid

Funding source Amount
Leadership and Comittment Scholarship (Canadians & permanent residents)
$30,000
Citizens of the World Scholarship (International students) $30,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies   
$20,000 to $70,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000. If you are benefiting of this scholarship program, the doctoral admission scholarship will go toward paying your supplemental tuition fees. You will not receive the $2,000 scholarship amount directly; rather it will be applied over your first two semesters to the supplemental portion of your tuition fees.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Doctorate in Physics

Program description

Financial Aid Available*

Financial Aid Related to Research Project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Progression scholarship
7 x $500
Doctoral exam or seminar presentation
$750
Doctoral exam, seminar or conference
$1,000
Publication
$750
Communication
$1,000
First submission of dissertation
$1,000*
Total $8,500

*A $500 bonus will be added to the graduation scholarship if the initial submission is made before the semester preceding the final qualifying semester.

Université Laval: Student Financial Aid

Funding source Amount
Leadership and Comittment Scholarship (Canadians & permanent residents)
$30,000
Citizens of the World Scholarship (International students) $30,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies   
$20,000 to $70,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000. If you are benefiting of this scholarship program, the doctoral admission scholarship will go toward paying your supplemental tuition fees. You will not receive the $2,000 scholarship amount directly; rather it will be applied over your first two semesters to the supplemental portion of your tuition fees.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's Degree in Biophotonics with thesis

Program description

Financial Aid Available*

Financial Aid Related to Research Project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Evaluated activity
$650
Achievement scholarship $1,000 
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Comittment Scholarship (Canadians & permanent residents) $10,000
Citizens of the World Scholarship (International students) $20,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies
$17,500 to $40,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's Degree in Physics with thesis

Program description

Financial Aid Available*

Financial Aid Related to Research Project

Information unavailable

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Evaluated activity
$650
Achievement scholarship $1,000 
Total $1,650

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Comittment Scholarship (Canadians & permanent residents) $10,000
Citizens of the World Scholarship (International students) $20,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies
$17,500 to $40,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Desired Profile

- Physics
- Physics Engineering

Requirements and Conditions

We are looking for enthusiastic, rigorous, hard-working, proactive, sociable students interested by the neuroimaging and qualified students with the following qualifications: B.Sc. or M.Sc. in a relevant discipline.

Required Documentation

- Cover letter
- Curriculum vitæ

Find Out More

Daniel Côté
Chercheur
Centre de recherche CERVO
daniel.cote@crulrg.ulaval.ca