Research project

Neurobiology of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Dementia

Description

Positions are available for outstanding students who are interested in pursuing a Master's and PhD degree in neuroscience. The major goal of my research is to determine how RNA processing is altered in ALS, and determine new therapeutic approaches to finding a cure for the disease. This will be accomplish by studying RNA-binding proteins that are mutated in ALS and assess their function. We will use new mouse models, which will develop ALS symptoms and cell culture models of ALS, to study the functions of RNA-binding proteins and the effects of therapeutics. Relevant findings will be confirmed in ALS patient samples. Findings from these studies will advance our understanding of how altered RNA regulation can cause ALS, and we will use this information to develop targeted therapeutics to cure the disease.

Research Field

- Neuroscience
- Biochemistry
- Translation
- RNA binding proteins
- Amyotrophic lateral sclerosis
- Frontotemporal lobar dementia

Research Supervisor

Chantelle Sephton

Research Environment

CERVO Brain research centre

Dr. Chantelle Sephton is seeking to recruit highly motivated students interested in pursuing a Master's (MSc) or Doctorate (PhD) degree in her laboratory in the Integrative Neuroscience Group at the CERVO Brain Research Center at Université Laval, Quebec City, Canada, https://cervo.ulaval.ca/en/chantelle-f-sephton.

The major goals of the Sephton laboratory are to determine how processing of RNA is altered in neurodegenerative disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD) and to identify new therapeutic approaches to finding a cure for these diseases. The Sephton laboratory uses ALS and FTLD mouse and cell culture models to study the function of RNA-binding proteins and the efficacy of therapeutics on preventing neurodegeneration. The laboratory takes a multifaceted approach in their research employing transcriptomics, proteomics, confocal and super resolution imaging. Students can look forward to a research intense environment and access to the state-of-the-art equipment. The Sephton Laboratory is a young dynamic and multilingual team and we would like to add highly motivated individuals to the group.

Web Site


Financial Aid Available by Program of Study

Doctorate in Cellular and Molecular Biology

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$21000 per year for 4 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Program progress award (S-1 to S-8)
8 x $525
Program progress award (S-9 to S-11) 3 x $200
Successful completion of Ph.D exam
$800
Submission of dissertation deposit before the end of the 12th semester
$2,000
Language training
$250
Total $7,850

Université Laval: Student Financial Aid

Funding source Amount
Leadership and Comittment Scholarship (Canadians & permanent residents)
$30,000
Citizens of the World Scholarship (International students) $30,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies   
$20,000 to $70,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000. If you are benefiting of this scholarship program, the doctoral admission scholarship will go toward paying your supplemental tuition fees. You will not receive the $2,000 scholarship amount directly; rather it will be applied over your first two semesters to the supplemental portion of your tuition fees.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Doctorate in Molecular Medicine

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$21000 per year for 4 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Program progress award (S-1 to S-8)
8 x $525
Program progress award (S-9 to S-11) 3 x $200
Successful completion of Ph.D exam
$800
Submission of dissertation deposit before the end of the 12th semester
$2,000
Language training
$250
Total $7,850

Université Laval: Student Financial Aid

Funding source Amount
Leadership and Comittment Scholarship (Canadians & permanent residents)
$30,000
Citizens of the World Scholarship (International students) $30,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies   
$20,000 to $70,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000. If you are benefiting of this scholarship program, the doctoral admission scholarship will go toward paying your supplemental tuition fees. You will not receive the $2,000 scholarship amount directly; rather it will be applied over your first two semesters to the supplemental portion of your tuition fees.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Doctorate in Neurosciences

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$21000 per year for 4 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
Program progress award (S-1 to S-8)
8 x $525
Program progress award (S-9 to S-11) 3 x $200
Successful completion of Ph.D exam
$800
Submission of dissertation deposit before the end of the 12th semester
$2,000
Language training
$250
Total $7,850

Université Laval: Student Financial Aid

Funding source Amount
Leadership and Comittment Scholarship (Canadians & permanent residents)
$30,000
Citizens of the World Scholarship (International students) $30,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies   
$20,000 to $70,000$
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000. If you are benefiting of this scholarship program, the doctoral admission scholarship will go toward paying your supplemental tuition fees. You will not receive the $2,000 scholarship amount directly; rather it will be applied over your first two semesters to the supplemental portion of your tuition fees.

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's Degree in Cellular and Molecular Biology with thesis

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$18000 per year for 2 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
First submission of thesis by the end of the 5th semester of full-time registration
$2,000
Language training
$250
Total $2,250

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Comittment Scholarship (Canadians & permanent residents) $10,000
Citizens of the World Scholarship (International students) $20,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies
$17,500 to $40,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's Degree in Molecular Medicine with thesis

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$18000 per year for 2 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
First submission of thesis by the end of the 5th semester of full-time registration
$2,000
Language training
$250
Total $2,250

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Comittment Scholarship (Canadians & permanent residents) $10,000
Citizens of the World Scholarship (International students) $20,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies
$17,500 to $40,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Master's Degree in Neurosciences with thesis

Program description

Financial Aid Available*

Financial Aid Related to Research Project

$18000 per year for 2 years.

Program-Specific Financial Aid

Graduate Studies Awards

Milestone Amount
First submission of thesis by the end of the 5th semester of full-time registration
$2,000
Language training
$250
Total $2,250

Université Laval: Student Financial Aid

Sources de financement Montant
Leadership and Comittment Scholarship (Canadians & permanent residents) $10,000
Citizens of the World Scholarship (International students) $20,000
Mobility Grant for Out-of-Province Internships or Research Visits (in French)
$1,000 to $2,000
Graduate Scholarships from Granting Agencies
$17,500 to $40,000
Online Directory of Graduate Scholarships (in French)
$500 to $50,000

* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.

Desired Profile

- Biomedical Science
- Neurology
- Biochemistry
- Biology
- Endocrinology and Metabolism
- Neuropathology

Required Documentation

- Cover letter
- Curriculum vitæ
- Student transcript
Please submit a letter of motivation, curriculum vitae, transcripts and two reference letters directly to Dr. Chantelle Sephton at chantelle.sephton.1@ulaval.ca. The application deadline is September 31st, 2020. In complete applications will not be considered.

Find Out More

Chantelle Sephton
Professeure agrégée/Associate Professor
Centre de recherche CERVO
chantelle.sephton.1@ulaval.ca