Re4search on the mutual host-microbiota relationships in the model C. elegans
Description
The rapid aging of the population demands concrete solutions to improve individual health. Through various collaborations, the research conducted is multidisciplinary in nature, ranging from molecular physiology in several preclinical models to cohort studies of patients.
As part of this extensive project, we use the bacterivore nematode C. elegans as an animal model (see our recent article https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0281887) to screen:
- The biological effects of microbiota from natural host ecogradients (age, sex, genetics, nutritional status, diet type, medication use, menstrual cycle, pregnancy, physical activity, circadian rhythm, light exposure, ambient temperature);
- Ways to prevent/improve aging dysbiosis using alternative means such as probiotics;
- The specific biological effects of bacterial species isolated from intestinal microbiota in individuals with obesity and diabetes;
- The effects of certain pharmacological agents on the market that could be used for other indications based on host microbiota.
Description of Tasks
- Actively and effectively contribute to an innovative research project by planning and conducting various experiments and measurements on the nematode after mastering the technical basics
- Contribute to the development of bold research hypotheses following readings of recent literature;
- Learn innovative techniques to make new breakthroughs;
- Participate in the writing of scientific articles and presentation of results at conferences;
Research Field
- Biomedical sciences
- Biology
- Immunology
- Biochemistry
- Physiology
- Endocrinology
- Aging
- Obesity
- Diabetes
Research Supervisor
Frédéric Picard
Research Environment
Quebec Heart and Lung Research Institute
The laboratory is located at the Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec and is affiliated with the Quebec Research Network on Aging (RQRV) and the network on cardiometabolism, obesity, and diabetes (CMDO). It is led by Dr. Frédéric Picard, a full professor at the Faculty of Pharmacy of Université Laval, and comprises a talented and dynamic team of graduate students and research professionals.
The laboratory is housed in inspiring facilities and equipped with state-of-the-art molecular physiology equipment, creating a stimulating scientific environment that fosters excellence and success. In the laboratory, students will be supervised and supported by the team throughout all stages of research. They will also participate in seminars and conferences regularly held at the research center and within our partner networks.
Web Site
Financial Aid Available by Program of Study
Doctorate in Pharmacy Science
Program descriptionFinancial Aid Available*
Financial Aid Related to Research Project
$8000 per term for 8 terms.
Regular work schedule of 7-8 hours per day, flexible according to experiments to be conducted and papers/articles to be written. A non-taxable scholarship of $8000/session is offered by the laboratory to successful applicants and will be adjusted according to the study program.
If the selected person additionally receives a scholarship from an external organization (e.g., FRQ, CRSNG, FER - Faculty of Pharmacy), the laboratory will enhance the remuneration. Dr. Picard's assistance in preparing scholarship applications is very significant. Interested candidates are therefore invited to contact Dr. Picard promptly to take advantage of these potential additional scholarship opportunities.
Program-Specific Financial Aid
Graduate Studies Awards
| Milestone |
Amount |
| Submission of the project outline |
$2,000 |
| Successful completion of the doctoral exam |
$1,000 |
| Successful completion of all courses by the end of the 8th semester |
$500 |
| Principal author of a first scientific article by the end of the 12th semester |
$1,000 |
| Principal author of a second scientific article by the end of the 12th semester |
$1,500 |
| Principal author of a literature review article or a third article by the end of the 12th semester |
$750 |
| Successful completion of the doctoral seminar and first submission of the dissertation by the end of the 12th semester |
$1,500 |
| Dissertation defence and final submission within 4 weeks of the defence |
$2,500 |
| Total |
$10,750 |
Teaching and Research Fund: Maximum amounts up to $17,500–$25,500 for doctoral students.
Université Laval: Student Financial Aid
Supplemental Tuition Fee Exemption Scholarship Program: Entitles international students to pay Canadian student tuition fees, for overall savings of around $40,000.
* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly. Master's Degree in Pharmacy Science with thesis
Program descriptionFinancial Aid Available*
Financial Aid Related to Research Project
$8000 per term for 4 terms.
Regular work schedule of 7-8 hours per day, flexible according to experiments to be conducted and papers/articles to be written. A non-taxable scholarship of $8000/session is offered by the laboratory to successful applicants and will be adjusted according to the study program.
If the selected person additionally receives a scholarship from an external organization (e.g., FRQ, CRSNG, FER - Faculty of Pharmacy), the laboratory will enhance the remuneration. Dr. Picard's assistance in preparing scholarship applications is very significant. Interested candidates are therefore invited to contact Dr. Picard promptly to take advantage of these potential additional scholarship opportunities.
Program-Specific Financial Aid
Graduate Studies Awards
| Milestone |
Amount |
| Submission of the project outline |
$500 |
| Successful completion of the research proposal during the 1st semester |
$250 |
| Successful completion of the seminar during the 6th semester |
$500 |
| Accelerated doctoral track / First submission of thesis |
$1,000/$500 |
| Total |
$1,750 (2,250$ if accelerated track) |
Teaching and Research Fund: Maximum amounts up to $12,500–$17,500 for Master’s students.
Université Laval: Student Financial Aid
* Amounts shown represent maximum financial aid available. Certain conditions apply. Subject to change without prior notice. For further information, contact sponsoring organizations directly.
Desired Profile
- Medecine
- Pharmacy
- Nursing
- Biomedical Science
- Biochemistry
- Biology
- Chemistry
- Kinesiology
- Microbiology
Requirements and Conditions
- Ongoing or completed studies in biology, biochemistry, biotechnology engineering, microbiology, pharmacy, pharmaceutical sciences, chemistry, immunology, or related discipline.
- Motivated, dynamic, and hardworking.
- Ambitious to make significant discoveries in the field
- Demonstrate rigor, determination, and teamwork.
- Have structured analytical skills
- Excellent communication skills, both oral and written.àPrevious experience working with C. elegans is an asset but not mandatory; the laboratory will teach all required techniques.
Required Documentation
- Text about research interests
- Cover letter
- Curriculum vitæ
- Student transcript
Names and contact information of two referees who have known the candidate in an academic and/or research context and/or work experience.
Send your documents directly to: frederic.picard@pha.ulaval.ca
Only shortlisted candidates will be contacted for an interview.
Application Deadline
May 14, 2024
Find Out More
Frédéric Picard
Professeur titulaire
Faculté de pharmacie
frpic33@ulaval.ca